Nasal Provocation Test with Cat and Dog Extracts: Results according to Molecular Components

Local and systemic effects of cat allergen nasal provocation.

BACKGROUND Cat allergen is widely distributed in homes and schools; allergic sensitization is common. OBJECTIVE To develop a model of cat allergen nasal challenge to establish dose-response and time-course characteristics and investigate local and systemic biomarkers of allergic inflammation. METHODS Nineteen cat-allergic individuals underwent titrated nasal challenge, range 0.243 to 14.6 μ...

Nasal provocation test: how to maximize its clinical use?

In order to diagnose allergic rhinitis (AR), skin prick tests and serum specific IgE level are the most common used methods. But there are some conditions which the results of both methods do not correlate with the clinical presentation of AR. Nasal provocation test is the method of detecting local IgE at the shock organ. There are some variations of NPT in terms of dosage, allergen administrat...

Nasal allergen provocation test in nasal polyposis with and without allergy

Methods Four groups of patients (n=48) underwent nasal allergen provocation test for grass pollen. We included 12 patients with allergic rhinitis based on grass allergy, 12 patients with CRSwNP without grass allergy, 12 patients with CRSwNP with grass allergy, and 12 control patients. The diagnosis of grass allergy was based on skin prick test and RAST. The test was positive based on change in ...

Leukotriene D4 nasal provocation test: Rationale, methodology and diagnostic value.

Cysteinyl leukotrienes (LT) play a vital role in the pathogenesis of allergic rhinitis (AR), but few studies have investigated the nasal mucosal physiological response to LTs in AR patients. The aim of the present study was to establish the methodology and investigate the diagnostic value and safety of a leukotriene D4 (LTD4) nasal provocation test. LTD4 nasal provocation tests were performed i...

Nasal Provocation Test in the Diagnosis of Allergic Rhinitis